Skin-Interfaced Wearable Sweat Biosensors for Personalized Healthcare
用于个性化医疗健康的可穿戴汗液生物传感器
Wei Gao（高伟）
ABSRACT
The rising research interest in personalized medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing wearable devices toward predictive analytics and treatment. In this talk, I will introduce our recent advances in developing fully-integrated skin-interfaced flexible biosensors for non-invasive molecular analysis. Such wearable biosensors can continuously, selectively, and accurately measure a wide spectrum of sweat analytes including metabolites, electrolytes, hormones, drugs, and other small molecules. These devices also allow us to gain real-time insight into the sweat secretion and gland physiology. The clinical value of our wearable sensing platforms is evaluated through multiple human studies involving both healthy and patient populations toward physiological monitoring, disease diagnosis, and drug monitoring. This talk will also feature our very recent works on laser-engraved lab on the skin and biofuel powered battery-free electronic skin toward metabolic/nutritional management as well as dynamic stress monitoring. These wearable and flexible devices could open the door to a wide range of personalized monitoring, diagnostic, and therapeutic applications.
基于柔性生物电子技术与功能材料器件的深入研究，个性化医疗健康领域得以快速发展，为病情诊断与术后治疗相关的可穿戴电子、柔性生物传感带来了令人振奋的研究契机。在这里，我将介绍我们在研发全集成皮肤界面的柔性生物传感器方面的相关工作，针对汗液中各类生物标志物，包括代谢物、电解质、激素、药物以及其他各类小分子等，进行了非侵入式的连续准确监测。通过健康人群与病患群体的临床医学研究，在生理信息监测、疾病诊断预警与药物输运等方面，对柔性生物传感器进行了可行性评估。在此基础上，我将进一步展示我们在实现新陈代谢健康管理与动态压力监测等方面的最近进展，研发了全激光加工的“皮肤上的实验室”以及生物燃料电池驱动的电子皮肤。这些可穿戴汗液生物传感平台的搭建，为实时监测-原位诊断-精准治疗的个性化医疗健康领域带来了全新的发展思路。
BIOGRAPHY
Wei Gao is an Assistant Professor of Medical Engineering in Division of Engineering and Applied Science at the California Institute of Technology. Originally from China, he earned his BS in mechanical engineering at Huazhong University of Science & Technology and his master’s in precision instruments from Tsinghua University. He received his Ph.D. in Chemical Engineering at University of California, San Diego in 2014 as a Jacobs Fellow and HHMI International Student Research Fellow. In 2014-2017, he was a postdoctoral fellow in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley.
He a recipient of IEEE Sensor Council Technical Achievement Award, Sensors Young Investigator Award, MIT Technology Review 35 Innovators Under 35 Global List (TR35) and ACS Young Investigator Award (Division of Inorganic Chemistry). He is also a member of Global Young Academy and ACS Nano Junior Fellow. His research interests include wearable devices, biosensors, flexible electronics, micro/nanorobotics, and nanomedicine. He has authored 100 publications in these fields and his articles have been cited more than 11,500 times (h-index: 56) as of April 2020. His work has been covered in a number of media worldwide including Nature, Science, The Wall Street Journal, New York Times, Time, Fortune, The Economist, Washington Post, NBC News, Discovery News, BBC News, Daily Mail, The Guardian, The Times, LA Times, Newsweek, Forbes, Fox News, Xinhua, Scientific American, IEEE Spectrum, MIT Technology Review, etc.
高伟教授现为加州理工学院医学工程系助理教授，2007年本科毕业于华中科技大学机械学院，2009年于清华大学精密仪器系获得硕士学位，2014年从加州大学圣地亚哥分校获得化学工程博士学位，并获得Jacobs Fellowship与HHMI International Student Research Fellowship的资助。2014年至2017年期间，在加州大学伯克利分校电子工程与计算科学系开展博士后工作研究。
高伟教授曾获评国际电气与电子工程师协会(IEEE)传感器理事会技术成就奖、美国化学学会(ACS)青年研究员奖等诸多奖项，入选麻省理工技术评论TR35全球榜单，并被选为全球青年学院会员与美国化学学会期刊ACS Nano的Junior Fellow。他的研究方向包括可穿戴设备、生物传感器、柔性电子、微纳机器人与纳米医学等。在相关领域发表学术论文近百篇，论文总引用次数超过11500次，H因子为56，相关工作被自然，科学，纽约时报，时代周刊，华尔街日报，经济学人，新闻周刊，财富，新华网等世界范围内多家知名媒体广泛报道。