Microtechnologies and nanotechnologies in drug delivery
基于微纳米技术的药物递送系统
Robert Langer
ABSRACT
Advanced drug delivery systems are having an enormous impact on human health. I start by discussing our early research on developing the controlled release systems for macromolecules and how that led to the isolation of the first angiogenesis inhibitors and then led to numerous new therapies, including nanoparticle-based drug delivery. I then discuss new oral delivery systems for macromolecules such as insulin. Finally, I discuss the development of approaches for creating new tissues and organs, including organs on a chip.
先进的药物递送系统对人类的健康有着巨大的影响。我将首先讨论我们早期对于大分子可控给药系统的研究，以及这些研究成果如何带来了第一个血管生成抑制剂的分离，并因此带来了许多新疗法，包括基于纳米颗粒的药物递送。然后，我将讨论大分子（例如胰岛素）的新型口服给药系统。最后，我会讨论我们在研发新的组织和器官上的进展，包括在器官芯片上的成果。
BIOGRAPHY
Robert Samuel Langer, the Germeshausen Professor of Chemical and Biomedical Engineering and maintains activity in the Department of Chemical Engineering and the Department of Biological Engineering at MIT. He is also a faculty member of the Harvard–MIT Program in Health Sciences and Technology and the Koch Institute for Integrative Cancer Research.
Langer holds over 1,400 granted or pending patents. He is one of the world's most highly cited researchers and his h-index is now 280 with currently over 325,000 citations. He is a widely recognized and cited researcher in biotechnology, especially in the fields of drug delivery systems and tissue engineering. He is the most cited engineer in history and tied for 4th most cited individual in any field,having authored over 1,500 scientific papers, and is also a prolific entrepreneur, having participated in the founding of over 40 biotechnology companies including Moderna.
Langer's research laboratory at MIT is the largest biomedical engineering lab in the world; maintaining over $10 million in annual grants and over 100 researchers. In 2015, Langer was awarded the Queen Elizabeth Prize for Engineering.
罗伯特·塞缪尔·兰格（Robert Samuel Langer）是麻省理工学院化学与生物医学工程系教授，并同时在化学工程系和生物工程系任教。他还是哈佛大学与麻省理工学院健康科学与技术计划以及科赫综合癌症研究所的教授。 兰格教授是生物工程学领域的著名学者，尤其以对靶向药物输送系统和组织工程学的研究而知名。兰格教授迄今发表过1500余篇论文，并拥有1400多项已获授权或正在申请的专利。兰格教授是全球引用量最高的科学家之一，他的h因子目前为280，被引用超过325000次，是历史上被引用次数最多的工程师，在所有的领域中被引用次数排名第四。兰格教授还是一位多产的企业家，参与了包括莫德纳在内的40多家生物技术公司的创立。兰格教授在麻省理工学院的实验室是全世界最大的生物医学工程实验室，该实验室保持着每年超过1000万美元的资金资助，拥有100多名研究人员。 2015年，兰格教授被授予伊丽莎白女王工程奖。