Implantable Optoelectronic Devices for Deep-Brain Neural Modulation and Sensing
面向新型神经接口的植入式微纳光电器件
Xing Sheng（盛兴）
ABSRACT
Bio-integrated high performance inorganic optoelectronic devices will provide new insights on interactions between light and bio-systems. Here we present unconventional strategies to design and fabricate thin-film, microscale optoelectronic devices and use them in implantable systems for deep brain neural signal modulation and sensing. Specifically, microscale LEDs are utilized to work as light sources to interact with genetically encoded neural actuators, stimulating neural activities, while photodetectors are used to monitor the fluorescence signals of light sensitive proteins, probing neural signals. Implanted devices are wirelessly powered and controlled by a miniaturized circuit system. These devices are implanted deeply into the mouse brain, demonstrating close loop monitoring and manipulation of neural activity in vivo. Such an integrated, deeply implanted and microscale optoelectronic system provides new insights on interactions between optical signals and neural systems.
微电子和光电子等信息器件与生物系统，特别是神经系统的集成逐渐成为一个重要的发展方向。我们通过探索新型的微纳器件工艺，结合光学、电学、力学的设计，开发微纳尺度的光电子材料与器件，并与柔性异质衬底进行集成，探索其在可穿戴、植入式等生物医疗领域的应用。本报告中，我计划探讨运用新型的光电材料与器件的设计方法和工艺策略，实现植入式的光电芯片，用于生物神经信号的监测和控制，以及生物体内的无线能量传输。具体而言，我将介绍基于微纳半导体光电器件的新型植入式神经接口，用于多通道、多光谱、多模态的无线在体神经信号检测与调控。
在未来，我们计划继续探索新型器件工艺，结合电路设计、能量传输、信号处理等多领域知识，开发新型多功能的神经科学传感、诊断、治疗系统。
BIOGRAPHY
Xing Sheng is currently an associate professor in the Department of Electronic Engineering at Tsinghua University, China. He obtained his PhD degree at Massachusetts Institute of Technology in 2012 (advisor: Lionel C. Kimerling), and his B.Eng degree at Tsinghua University in 2007. From 2012 to 2015, he was a postdoctoral researcher at University of Illinois at Urbana-Champaign (advisor: John A. Rogers). He has published more than 40 papers (including 5 invited papers) in peer-reviewed journals like Nature Materials, PNAS, Advanced Materials, etc. He is currently serving as an associate editor for OSA Optical Materials Express. He is selected into the “1000 Youth Talents Program” in 2015. His research interests are primarily in manipulating materials and photonic structures for micro- and nano-scale optoelectronic devices, to enable high performance and versatile functionalities. His recent efforts focus on light management in microscale devices (solar cells, LEDs, etc) for solar energy harvesting and biomedical applications.
盛兴，目前就职于清华大学电子工程系，担任副教授。他于2012年在美国麻省理工学院获得博士学位（导师：Lionel C. Kimerling），并于2007年在清华大学获得工学学士学位。2012年至2015年，他在美国伊利诺伊大学厄巴纳分校担任博士后研究员（导师：John A. Rogers）。他在Nature Materials, PNAS, Advanced Materials等期刊上发表了40多篇论文（包括5篇受邀论文）。他目前是OSA Optical Materials Express的编辑。他的主要研究兴趣是开发新型的光电子材料与器件，用于生物医疗技术。