New hybrid materials for ultrasensitive biosensing and regenerative medicine
用于超灵敏生物传感与可再生医学的新型复合材料
Molly M. Stevens
ABSRACT
This talk will provide an overview of our recent developments in bio-responsive hybrid materials which are of growing importance in the field of disease diagnostics and regenerative medicine. We engineer new approaches to detect disease biomarkers, such as abnormally regulated enzymes, to extend the detection window for early disease diagnostics and develop high throughput drug screening platforms. This talk will describe our research on the design of polymeric and inorganic nanomaterials for developing sensitive detection assays that are simple, cost-effective and easy deploy to the point-of-care. We are exploiting the sensing capabilities of nanoparticles to engineer paper-based lateral flow immunoassays (LFIAs) and nanosensors for in vivo disease diagnostics that produce a colorimetric response ideal naked eye read-out. We integrate our nanomaterial based assays into smartphone enabled diagnostic tests for patient self-monitoring, geographical tagging and epidemic surveillance. We have also developed different platforms of nanoneedles capable of interfacing with cells to inform multiplexed intracellular biosensing at sub-cellular resolution and modulate biological processes. Recent developments in this context will be discussed.
在本次讲座中，我们将概述在生物反应性复合材料领域的最新发展，这些材料在疾病诊断与可再生医学领域发挥着越来越重要的作用。通过设计检测疾病生物标志物（如异常调节酶等）的新方法，来拓展早期疾病检测窗口并研发高通量药物筛选平台。同时，为了实现高效灵敏、简单可行、成本可控的检测手段，我们进一步对聚合物与无机纳米材料设计展开研究。利用纳米颗粒的传感能力来实现纸基的横向流动免疫分析和用于体内疾病诊断的纳米传感器，并通过肉眼可见的比色响应进行数据读取。进一步将纳米材料的分析与智能手机应用诊断测试相集成，实现患者自我监测、地理位置记录以及流行病监控。同时，我们还开发了不同的纳米针尖平台，与细胞界面相连接，提供亚细胞分辨率的多模态生物传感信息，并进一步调控生物过程。
BIOGRAPHY
Molly M. Stevens is currently Professor of Biomedical Materials and Regenerative Medicine & Research Director for Biomedical Material Sciences in the Department of Materials, Department of Bioengineering and the Institute of Biomedical Engineering at Imperial College London. She received her PhD from The University of Nottingham in 2000, working within the School of Pharmaceutical Sciences. She conducted her postdoctoral research within the Department of Chemical Engineering at MIT in the labs of Prof Robert Langer, where she co-developed innovative techniques for the regenerative of bone and other tissues. She joined Imperial College in 2004 and was promoted as Professor in 2008. Research in the Stevens Programme focusses on designing and developing innovative bio-inspired materials for applications in regenerative medicine, tissue engineering and biosensing.
Molly Stevens’ research has been recognised by over 20 major awards, such as the 2016 Clemson Award for Basic Research from the Society for Biomaterials, the EU40 Prize for best material scientist under the age of 40, a listing in The Times as one of the top 10 scientists under 40 and the European Life Sciences 2014 Research Group of the Year Award, amongst many others. She was recently elected to the Fellowship of the Royal Society and is also a Fellow of the Royal Academy of Engineering and a Foreign Member of the US National Academy of Engineering. She has previously served on the Board of Reviewing Editor for Science and is Associate Editor of ACS Nano. More information on the Stevens Group can be found athttp://www.stevensgroup.org.
Molly M. Stevens教授现为帝国理工学院材料系、生物工程系和生物医学工程研究所的生物医学材料与可再生医学教授兼生物医学材料科学研究室主任。她2000年从诺丁汉大学药学院获得博士学位，之后在麻省理工学院化学工程系Robert Langer教授组开展博士后研究，合作开发了骨头与其他组织可再生的创新技术。之后，她于2004年加入帝国理工学院，并在2008年晋升为教授。Stevens教授课题组研究重点在于设计并开发创新的仿生材料，用于可再生医学、组织工程以及生物传感等领域之中。
Molly Stevens教授获得了20余个重要奖项的认可，包括2016年度生物材料协会的Clemson基础研究奖、欧盟40名40岁以下最佳材料科学家、《泰晤士报》十大40岁以下科学家以及2014年度欧洲生命科学研究小组奖等。同时，她被选为皇家学会研究员，也是英国皇家工程院Fellow和美国国家工程院外籍成员。她曾在Science杂志的评委编辑委员会任职，现为ACS Nano的副主编。关于Stevens研究小组的更多介绍，请参考课题组主页：http://www.stevensgroup.org。